In life, kidney failure patients are becoming more and more. For chronic renal failure, anemia clinical phenomenon is very normal, so, why kidney failure could lead to anemia?
The most common anemia is caused by erythropoietin reducing. Erythropoietin mainly reduced by glomerular juxtaglomerular cells and medullary stroma cells. Kidney failure patients’ kidney erythropoietin production parts damaged lower hemoglobin affinity for oxygen and unit for oxygen utilization increase hemoglobin, renal ischemia is less serious at this time. The main produces of erythropoietin stimulating reduced, resulting in significantly reduced the generation of erythropoietin. Blood accumulation of some toxic materials has direct inhibition on bone marrow;, and this situation would lead to hematopoietic dysfunction.
In addition, increasing in the number of red blood cell damage is also one of the causes of anemia. This is due to high blood polyamine leads to red blood cell life-span is shortened. In uremia period, metabolic disorders of red cells and erythrocyte fragility increases, finally this situation causes the autolysis of red blood cell.
Red blood cell loss increased and chronic stomach digestive tract occult bleeding could aggravate chronic kidney failure patient’s conditions. Other diseases like high blood pressure may affect the hematopoietic function, may also affect the body’s absorption of nutrition, finally this situation would cause malnutrition then lead to renal failure.
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